Rachelle Gaudet
Structural biology of membrane transport

X-ray crystallography and other biophysical and biochemical techniques are combined to study the stereochemistry of signaling and transport through biological membranes. Studies focus on two subjects. First, a diverse family of TRP channels, with particular emphasis on how certain members of this group sense and respond to heat and pain. Second, TAP, the transporter associated with antigen processing, which moves peptides generated by the proteosome in the cytosol into the endoplasmic reticulum.

Publications:
C.B. Phelps and R. Gaudet (2007) The Role of the N-Terminus and Transmembrane Domain of TRPM8 in Channel Localization and Tetramerization. J. Biol. Chem. 282, 36474-80.

P.V. Lishko, E. Procko, X. Jin, C.B. Phelps and R. Gaudet (2007) The Ankyrin Repeats of TRPVI Bind Multiple Ligands and Modulate Channel Sensitivity. Neuron 54, 905-918.

E. Procko, I. Ferrin-O'Connell, S.-L. Ng and R. Gaudet (2006) Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter. Mol. Cell 24, 51-62.